Endocrine Abstracts

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Background- The reduced survival in acromegaly is strongly related to high serum Growth hormone (GH) concentrations. This increased mortality is proportional to the GH excess on day curve data and hence reduction can improve mortalilty to normal levels. The threshold ofcure has changed over the last three decades and additional parameters have been introduced to assess disease activity.Aim- To compare GH measurement equivalence dur...

A 52 year old man presented with a 4 week history of heartburn and epigastric pain. On examination 6 centimetres of irregular heptomegaly were palpable extending across to the epigastrium. Ultrasound of the abdomen demonstrated multiple liver metastases. Percutaneous liver biopsy was consistent with a neuroendocrine tumour (NET) with positive staining for CAM 5.2, chromogranin, PGP 9.5 and S100 but negative for alpha fetoprotein and CEA. Gamma glutamyl transpepitdase was eleva...

Expression of the mt1 melatonin receptor has been described in both the pars tuberalis (PT) and pars distalis (PD) of the rat pituitary gland. Expression of mt1 mRNA and iodomelatonin (IMEL) binding sites is high in the neonate PD but rapidly declines over the initial weeks of postnatal life. In contrast, both mt1 mRNA and IMEL binding sites are preserved in the PT through to adulthood, leading to a marked tissue-specific expression profile.To identify ...

Background: Head and neck paragangliomas (HNPGL) are rare, usually benign slow-growing tumours arising from neural crest-derived tissue. Definitive treatment strategies for HNPGL have not been clearly defined.Aims: To provide a comprehensive review of our institutional experience of the clinical features, investigations, management and follow up of this cohort.Methods: Baseline clinical information was taken from a prospectively ma...